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doi:10.1089/ars.2012.4644, PMID: 22530666 Franco R, Panayiotidis MI, Cidlowski JA (2007) Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation

Reported issues at therapeutic doses are mild and uncommon, and include local injection-site reactions, occasional dizziness, and transient changes in blood pressure [Sikiric et al., Inflammopharmacology, 2018]

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The protective effect of GSH was also seen in vehicle control cells, which likely experienced some oxidative stress attributable to the toxic effects of the DMSO vehicle (Figure 3 in the 0 M ITZ treatment groups, which contained no ITZ but were treated with the DMSO vehicle

Similar formulations are also used in hair and scalp products

Rodent toxicity studies from the Sikiric group have not identified significant acute toxicity